Glucose levels are considered a major determinant of the aging process. Many age-related diseases occur earlier in life, in diabetic patients compared to healthy individuals. In fact, increased glucose level as an “aging accelerator” has been supported by several research findings.
Skin aging is also linked to glucose levels. Extensive exposure to hyperglycemic conditions causes premature cellular senescence in human skin fibroblasts.
Advanced glycation end products (AGEs) are formed through a type of non-enzymatic reaction called glycation. Diabetic patients display a higher degree of cross-links in their collagen, which is assumed to be mainly caused by advanced glycation end products (AGEs). The cross-links in collagen prevent efficient repair, which in turn will cause premature aging of the skin.
Credits: Yashimi Byakodi
